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What does dredge 6 mean11/15/2023 A study indicates that older age, cardiovascular drugs, and preexisting nerve compression syndromes are likely to increase neuropathy risk. And the route of drug administration is considered as an important factor in the development of CIPN. Research reports that paclitaxel-induced mechanical allodynia is due to the transcriptional increase in matrix metalloproteinases (MMP) 2 and 9 and decrease of metallopeptidase inhibitor 1 (TIMP1). 16% for FOLFOX.) Besides, CIPN apparently increases the financial burden on patients as well as the annual costs of healthcare. 6-month treatment of CapeOX or FOLFOX.(3% vs. found that high-grade CIPN (grades 3-4) was more likely to occur in 3-month treatment vs. Those side effects can result in a dose reduction of chemotherapy regime, even terminating the course of treatment, thus limiting therapeutic efficacy. Pain CIPN can be extremely disabling, with a marked impact on quality of life, functional ability, and risks of noncompliance with cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is an inevitable dose-limiting side effect and approximately 30–40% of patients treated with neurotoxic chemotherapy agents, such as platinum, vinca alkaloids, and taxanes, will suffer from it.
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